Background: Chronic kidney disease (CKD) is a common problem globally and has heavy burden on patients and health authorities. Knowing the risk factors of CKD will reduce the prevalence of CKD and its socio-economic effects. Aim of study: To determine the risk factors that lead to CKD in Libyan patients. Method: Cross-sectional study based on single-center experience. Two-hundreds and four out-patient’s notes were reviewed. All were adults aged >18 years. Result: Records of 204 CKD patients were reviewed, 55.4% female and 91 (44.6%) patients were male. Patient’s mean age was 51.9 ± 15.7 years, and there was not significant difference between the mean ages of both sexes. Patient’s distribution at presentation according to CKD stages was stage-I (15.7%), stage-II (16.7%), stage-III (34.8%), stage-IV (19.6%) and stage-V (13.2%). Diabetes mellitus (DM) as a cause of CKD reported in (49%), glomerulonephritis (GN) in (17.6%) and hypertension (HTN) in (9.3%) of patients. More than 50% of the patients had strong family history of CKD. Unidentifiable cause of CKD recorded in 4.9%. Conclusions: Stage-III is the commonest stage of CKD at presentation. DM, GN and HTN respectively are the common cause of CKD. Good control of DM and HTN reduces risk of CKD and renal failure significantly.